GENOME-WIDE IDENTIFICATION OF REPLICATION FORK STALLING/PAUSING SITES AND THE INTERPLAY BETWEEN RNA POL II TRANSCRIPTION AND DNA REPLICATION PROGRESSION

Abstract Background DNA replication progression can be affected by the presence of physical barriers like the RNA polymerases, leading to replication stress and DNA damage.Nonetheless, we do not know how transcription influences overall DNA replication progression.Results To characterize sites where DNA replication forks stall and pause, we establi

This paper introduces a novel integration method of localized metallic back-gates into fully-depleted silicon-on-insulator (FDSOI) multi-gate FETs, enabling robust front-to-back electrostatic coupling from room temperature to cryogenic conditions, without the need for substrate implantation.The fabrication process, termed the Nanomole process, util

Objective: To present a descriptive analysis of patients diagnosed with multiple myeloma, correlating it with mortality.Methods: A retrospective study that analyzed consecutive patients QUERCETIN COMPLEX diagnosed with multiple myeloma under follow-up at the Faculdade de Medicina do ABC from 2006 to 2010.Results: The median age was 58.5 years.Anemi

Compared with carbon steel, traces of Ni, Cr, Ti, and other corrosion-resistant alloying elements were added to the matrix of bridge weathering steel, which resulted in the steel surface forming a strong adhesion and dense patina that hindered the penetration of atmospheric oxygen elements into the steel and significantly Rug delayed the developmen